If you have any questions, ask your doctor or pharmacist. Potensi Tinggi Setiap kapsul mengandung 1.000 mg milk thistle untuk memberikan dukungan hati yang kuat dan mengandung tambahan 50 mg akar dandelion untuk manfaat tambahan. 2008;47(2):605-12. doi:10.1002/hep.22044, Voroneanu, L.; Nistor, I.; Dumea, R. et al. In this way, milk thistle may help improve cognition and treat degenerative conditions that affect the mind. Seeff LB, Curto TM, Szabo G, et al. It will also cover milk thistle side effects, precautions, dosage, and interactions. Together, you can make shared, well-informed decisions. Achufusi TGO, Patel RK. A double-blind controlled study. Does milk thistle cause any side effects? Side effects are always possible when taking supplements. However, more research is needed to understand the benefits of milk thistle on humans. (2021). Similarly, the fact that milk thistle does not affect digoxin pharmacokinetics suggests no effect on P-gp (ABCB1), although there is other evidence of inhibition. Although there are some conflicting data, such as a possible inhibition of the CYP2C9 metabolism of losartan, most of the data suggest a minimal effect of milk thistle on CYP450 isozymes. Call your doctor for medical advice about side effects. An older study found that milk thistle extract had a positive effect on immune response in humans. Despite having nothing to do with milk, the milk thistle plant, also known as Silybum marianum, is a popular herb for treating and preventing a variety of diseases.. Loguercio C, Festi D. Silybin and the liver: from basic research to clinical practice. Silymarin, an active component of milk thistle, has been reported to be safe at doses of 700 milligrams three times a day for 24 weeks. Limited laboratory research suggests that the compound silibinin in milk thistle may help to prevent breast cancer, according to the NIH. Properly discard this product when it is expired or no longer needed. 2020;34(6):1446-1454. doi:10.1002/ptr.6620. Of the total drug interactions, 3 are moderate, and 1 is minor. Drug-drug Interactions of Silymarin on the Perspective of Pharmacokinetics, Journal of Ethnopharmacology, US National Library of Medicine, National Institutes of Health. What is the daily upper limit for milk thistle? Researchers have found benefits for several types of cancer, including: Several small studies have also found that milk thistle may decrease the side effects of cancer treatments, including radiation, surgery, and chemotherapy. However, there is no solid evidence that supports these claims. The antioxidant properties of milk thistle can regenerate and minimize the damages in the liver cells which are done by consuming alcohol (1). Other potential benefits include . Call your doctor for medical advice about side effects. Enter your medication into the WebMD interaction checker, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Fitness vs. However, researchers theorize that it does. National Center for Complementary and Integrative Health. In a recent study, milk thistle was found to markedly inhibit raloxifene glucuronidation at both glucuronidation sites and by all glucuronidation enzyme systems. The common name, milk thistle, is derived from the "milky white" veins on the leaves, which, when broken open, yield a milky sap. Soy Protein Vs. Whey Protein: Pros And Con Soy Protein Vs. Whey Protein: Pros And Cons + Which Is Better. Milk thistle may lower blood sugar levels in people with type 2 diabetes. Content is best viewed in IE9 or above, Firefox and Google Chrome browser. StyleCraze provides content of general nature that is designed for informational purposes only. Milk thistle ( Silybum marianum ) is a flowering herb native to Europe but also found in parts of the United States, Australia, Asia, Africa, and South America. Common side effects of milk thistle may include: indigestion, bloating, gas, stomach pain; diarrhea; or. However, the extracts in milk thistle could act like estrogen. Can diet help improve depression symptoms? Milk thistle (Silybum marianum) is a flowering herb native to Europe but also found in parts of the United States, Australia, Asia, Africa, and South America. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. Hepatology. Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. The most common use of milk thistle is for liver problems. If drinking milk thistle tea, it is best to limit intake to 6 cups a day. If left untreated, anaphylaxis can lead to shock, coma, cardiac or respiratory failure, or even death. JAMA. Rarely, taking milk thistle may cause: There is not much information about the interaction of milk thistle with other drugs, including anticancer medications and radiation therapy. It is also unknown whether milk thistle is safe for children. WebMD does not provide medical advice, diagnosis or treatment. 1997-. However, consult a doctor to figure out the daily recommended dosage of this herb. There are other supplements that work similarly to milk thistle. Cathy Wong is a nutritionist and wellness expert. However, many of these potential benefits are not backed by science. Calm an upset stomach. Follow all directions on the product package. Milk thistle has a range of potential health benefits due to its active ingredient, silymarin, which is an antioxidant. 2016;2016:5147468. doi:10.1155/2016/5147468. Although milk thistle may be helpful in hepatitis C, more research is needed to support these claims. Medications known to interact with milk thistle Note: Showing generic names only. Current studies on milk thistle use a wide range of doses. Some people may be allergic to milk thistle. She has 14 years of experience in Clinical Nutrition as well as teaching Nutrition and Dietetics to undergraduate and postgraduate students. It also seems to have antioxidant and anti-inflammatory effects. These combination supplements may list health claims on the label. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Milk thistle Interactions There are 4 drugs known to interact with milk thistle . The following list is not exhaustive. The plants are native to the Mediterranean regions of Europe, North Africa, and the Middle East.One species has been introduced elsewhere, including in North America. Due to the lack of regulation, supplement quality can vary from one brand to the next. Medical research on milk thistle and liver health has led to mixed results. In some studies, silibinin, an active component of milk thistle, has been shown to have estrogen-like effects. Monk Fruit: Nutrition, Benefits, And Side Monk Fruit: Nutrition, Benefits, And Side Effects, Seitan Nutrition Benefits, Side Effects, & How To Make It, 12 Health Benefits Of Milk Thistle, Nutrition, & Side Effects, 15 Serious Side Effects Of Ashwagandha & Precautions To Take, 10 Amazing Health Benefits Of Buckwheat Tea. Milk thistle (PDQ) patient version. Milk Thistle; Silybum marianum; St. Mary's Thistle. Sources of Milk Thistle & What to Look For, Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases, Silymarin as supportive treatment in liver diseases: a narrative review, Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial, Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial, Effects of Silybum marianum (L.) Gaertn. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, Complementary Medicine / Alternative Medicine, https://www.ncbi.nlm.nih.gov/books/NBK541075/, https://www.ncbi.nlm.nih.gov/pubmed/20564545, https://pubmed.ncbi.nlm.nih.gov/21786113/, https://www.ncbi.nlm.nih.gov/pubmed/22842463, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7248929/, https://bnrc.springeropen.com/articles/10.1186/s42269-021-00567-1, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4866124/, https://www.ncbi.nlm.nih.gov/pubmed/27387273, https://www.ncbi.nlm.nih.gov/pubmed/17072885, https://www.tandfonline.com/doi/full/10.1080/0886022X.2016.1244070, https://www.hindawi.com/journals/bmri/2013/919374/, https://www.ncbi.nlm.nih.gov/pubmed/25613505, https://www.ncbi.nlm.nih.gov/pubmed/26345246, https://www.karger.com/Article/FullText/506651, http://jddonline.com/articles/dermatology/S1545961613P0780X, https://www.cancer.gov/about-cancer/treatment/cam/hp/milk-thistle-pdq, https://www.cancer.gov/about-cancer/treatment/cam/patient/milk-thistle-pdq, https://www.komen.org/breast-cancer/survivorship/complementary-therapies/milk-thistle/, https://www.nccih.nih.gov/health/milk-thistle, http://www.tandfonline.com/doi/abs/10.1080/00071668.2015.1121537?journalCode=cbps20, https://www.elsevier.es/en-revista-allergologia-et-immunopathologia-105-articulo-immunomodulatory-effects-two-silymarin-isomers-S030105462030029X, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138577/, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4116427/, https://www.ajol.info/index.php/ijbcs/article/view/127127, https://www.jmbfs.org/issue/february-march-2020-vol-9-no-4/jmbfs_2092fbfs_valkova/?issue_id=6515&article_id=30, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC6470681/, https://www.ncbi.nlm.nih.gov/pubmed/12444368, Common sweetener erythritol tied to higher risk of stroke and heart attack, Gout: How metabolic syndrome may increase the risk, A new therapeutic target for the prevention of heart failure due to aortic stenosis, Skipping breakfast and fasting may compromise the immune system. Milk thistle is a natural herb with antioxidant and anti-inflammatory properties. The study looked specifically at bone loss caused by a deficiency in estrogen among rats that had their ovaries removed. People can purchase milk thistle supplements in health food stores or online. She was awarded the Pr more, Ravi Teja Tadimalla , Professional Certificate In Food, Nutrition & Health, Ravi Teja Tadimalla is an editor and a published author. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. You may report side effects to FDA at 1-800-FDA-1088. A 2020 narrative review detailing silymarin's potential uses for the liver noted its antioxidant-like effects in people with cirrhosis. However, there are a few side effects of milk thistle associated with its excess intake. Effect of silymarin supplement on the pharmacokinetics of rosuvastatin. increased sweating. It reportedly has other potential health benefits, which may include: Due to some similar potential health benefits, producers have studied milk thistle and dandelion supplements and sold them together. Before using this product, tell your doctor or pharmacist of all the products you use. A 2019 6 Molecules 6 review 6 found that silymarin exhibits anti-collagenase and anti-elastase activity, meaning it protects the breakdown of collagen and promotes skin strength and elasticity. If necessary, be sure to check the label to learn if a supplement is vegan or not. What should I know regarding pregnancy, nursing and administering Milk Thistle Capsule to children or the elderly. Voroneanu L, Nistor I, Dumea R, Apetrii M, Covic A. Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. Silybum (milk thistle) is a genus of two species of thistles in the family Asteraceae. A small number of studies have suggested that milk thistle extract might be beneficial for diabetes, but the conclusions about its effectiveness are not definite. Possibly. Certain people should take precautions when using milk thistle, and others may need to avoid it altogether. This prickly plant has distinctive purple flowers and white veins, which traditional. This suggests milk thistle may be beneficial for those looking to lose weight. ODS seeks to strengthen knowledge and understanding of dietary supplements by evaluating scientific information, supporting research, sharing research results, and educating the public. Milk thistle (Silybum marianum) is a flowering plant that comes from the same family as the daisy. It is not yet clear whether milk thistle is equally beneficial for bone loss with a different cause. ), SAGE Journals. A recent study suggested that milk thistle may substantially increase systemic exposure of the antibreast cancer drug raloxifene.1. A systematic review (summary of medical literature on a specific topic) conducted in 2016 further concluded that using silymarin regularly may reduce fasting blood glucose and HbA1C levels, two important factors in diabetes management. Some such drugs may include (12): Since milk thistle affects how well the liver breaks down these medications, it can affect how well these medications can work. The terms "milk thistle" and "silymarin" are often used interchangeably. Substances in milk thistle may reduce blood sugar. Milk thistle had no effect on any of the drugs. How this happens is yet to be studied. Take this product by mouth as directed. Similar to milk thistle, dandelion (Taraxacum officinale) has antioxidant effects. Eighteen clinical trials of 1,088 participants were assessed. There is no standard dose of milk thistle, so it is best to read the dosage suggested on the packaging. Expert: Infusion Pharmacy Technicians Can Reduce Workload in Oncology Pharmacy, Clinical Forum Recap Data Show Melanoma Site to Be Independent High-Risk Factor for Recurrence, Poor Outcomes, Improving Postoperative Pain Management in Patients with Complicated Pain, FAST Generics Act Reintroduced in Congress, FDA Concedes Agency Has Difficulty Adequately Regulating Generics, Hepatitis C Activity Inhibited by OTC Allergy Drug, 3-Drug Therapy Deemed Effective Hepatitis C Treatment, Treating Hepatitis C May Yield Economic Benefits, Examining Recent Advances in Understanding and Treatment of Dry Eye Disease: An Eye on the Pharmacist's Role, Counseling Skills You Didn't Learn in Pharmacy School, Vitamin D Supplementation and Fall Prevention in the Elderly. Call your doctor for medical advice about side effects. Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials. The medical community needs more evidence to prove that milk thistle benefits human livers in the same way. A 2006 study suggests that milk thistle may play a role in keeping cholesterol levels down. Evidence and risks, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, protecting the liver, immune system, and kidneys, providing antiviral, antifungal, and antibacterial properties, reducing the risk of diabetes, arthritis, and obesity. Health has led to mixed results postgraduate students that comes from the same way also cover thistle! In IE9 or above, Firefox and Google Chrome browser Perspective of Pharmacokinetics, Journal of Ethnopharmacology, National. Family Asteraceae for liver problems when using milk thistle is for liver problems ; St. Mary 's thistle ;... Of general nature that is designed for informational purposes only a meta-analysis of controlled... Ethnopharmacology, US National Library of Medicine, National Institutes of health children or elderly... 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